Tying-up tuberculosis

Tying up syntactic loose ends

Hyaluronan-binding proteins: tying up the giant.

The ubiquitous glycosaminoglycan (GAG) hyaluronan has diverse biological roles in vertebrates. These include acting as a vital structural component of connective tissues, the formation of loose hydrated matrices that allow cells to divide and migrate (e.g. during development), immune cell adhesion and activation, and a role in intracellular signaling (1–3). This wide range of activities may see...

Tying up Loose Ends in Chondrule Formation by Shocks

Chondrule formation is a long-standing problem in meteoritics. Furnace experiments designed to reproduce chondrule textures constrain their cooling rates between their liquidus and solidus temperatures to be in the range 10-1000 K/hr [1]. This constraint, and nearly all other known constraints on chondrule formation, are satisfied if chondrules were melted by passage through solar nebula shocks...

Tying up loose ends: ribosome recycling in eukaryotes and archaea.

Ribosome recycling is the final - or first - step of the cyclic process of mRNA translation. In eukaryotes and archaea, dissociation of the two ribosomal subunits proceeds in a fundamentally different way than in bacteria. It requires the ABC-type ATPase ABCE1 [previously named RNase L inhibitor (Rli)1 or host protein (HP)68], but the reaction and its regulation remain enigmatic. Here, we focus...

Hyaluronan - binding proteins : tying up the giant Anthony

Introduction The ubiquitous glycosaminoglycan (GAG) hyaluronan has diverse biological roles in vertebrates. These include acting as a vital structural component of connective tissues, the formation of loose hydrated matrices that allow cells to divide and migrate (e.g., during development), immune cell adhesion and activation, and a role in intracellular signaling; further details can be found ...